Pharmaceutical Cocrystals: New Solid Phase Modification ...

    pharmaceutics Review Pharmaceutical Cocrystals: New Solid Phase Modification Approaches for the Formulation of APIs Anna Karagianni 1, Maria Malamatari 2 ID and Kyriakos Kachrimanis 1,* 1 Department of Pharmaceutical Technology, Aristotle University of Thessaloniki, 54351 Thessaloniki, Greece; [email protected]

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    o Solid State Characterization and Tableting Studies of ...

    cocrystals of fenofibrate with nicotinamide by solution cocrystallization technique, solid state characterization of cocrystals by FTIR, PXRD and Raman spectroscopy and to evaluate cocrystals for tableting performance. MATERIALS AND METHODS Materials Fenofibrate was obtained as a gift sample from Alembic pharma, Pvt.Ltd. Vadodara.

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    UNDERSTANDING THE SOLUTION PHASE CHEMISTRY AND .

    UNDERSTANDING THE SOLUTION PHASE CHEMISTRY AND SOLID STATE THERMODYNAMIC BEHAVIOR OF PHARMACEUTICAL COCRYSTALS . by . Chinmay Maheshwari . A dissertation submitted in the partial fulfillment . of the requirements for the degree of . Doctor of Philosophy (Pharmaceutical Sciences) in the University of Michigan . 2012 . Doctoral Committee:

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    Pharmaceutical Cocrystals and Their Physicochemical Properties

    Jun 03, 2009 · Currently, salt formation is one of the primary solid-state approaches used to modify the physical properties of APIs, and it is estimated that over half of the medicines on the market are administered as salts.() However, a major limitation within this approach is that the API must possess a suitable (basic or acidic) ionizable site.In comparison, cocrystals (multicomponent assemblies held ...

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    The role of higher coformer stoichiometry ratio in ...

    The role of higher coformer stoichiometry ratio in pharmaceutical cocrystals for improving their solid-state properties: The cocrystals of progesterone and 4-hydroxybenzoic acid. Author links open overlay panel Marivel Samipillai Sohrab Rohani. Show more.

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    Pharmaceutical Cocrystal Drug Products: An Outlook on ...

    Active pharmaceutical ingredients (APIs) are most commonly formulated and delivered to patients in the solid state. Recently, an alternative API solid-state form, namely the pharmaceutical cocrystal, has witnessed increasing academic and industrial interest due to its potential to deliver bespoke physical properties in the pharmaceutical drug product.

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    Interrelation of the dissolution behavior and solid-state ...

    Jan 01, 2017 · The series of cocrystals examined herein exhibits an inverse correlation between the intrinsic dissolution rates and the melting/decomposition temperatures as well as the dimension of the hydrogen-bonded ACZ aggregates found in the corresponding crystal structure, indicating that solid-state stability is the major influence on dissolution ...

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    Pharmaceutical Cocrystals: An Overview - ijpsonline

    The generally accepted definition of cocrystals was proposed by 46 scientists during the Indo-US Bilateral Meeting sponsored by the Indo-US Science and Technology Forum titled "The Evolving Role of Solid State Chemistry in Pharmaceutical Science", which was organized in Delhi, India in 2012.

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    The role of cocrystals in solid-state synthesis of imides ...

    41 Cocrystals in solid-state synthesis and cocrystals in pharmaceutical development both show great promise in their respective area s. Cocrystals as reaction intermediates or photodimerization templates have afforded novel materials typical ly coupled with increased reaction yields.

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    Crystal Engineering of Organic Cocrystals by the Solid ...

    Crystal engineering of organic cocrystals is gaining interest across a variety of disciplines. The solid-state grinding approach to preparing cocrystals is an alternative to the traditional method ...

    Author: Andrew V Trask, William Jones
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    Crystals | Free Full-Text | Structural Characterization of ...

    Cocrystallization methods including solvent evaporation, solid-state grinding, slurry, solvent drop, supercritical fluid, and the use of anti-solvent have been widely applied to produce cocrystals . The solid-state NMR is an analytical technique used for determining the crystal structure of materials.

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    Polymorph Screening and Salt Selection Pharmaceutical ...

    Triclinic Labs is the leading provider of comprehensive solid-state chemical development and testing services. Polymorph Screening and Salt Selection Services for physico-chemical property improvement and intellectual property support during drug development

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    Crystal Engineering of Organic Cocrystals by the Solid ...

    Crystal engineering of organic cocrystals is gaining interest across a variety of disciplines. The solid-state grinding approach to preparing cocrystals is an alternative to the traditional method ...

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    Solid State Photoreactions of Organic Cocrystals and Alloys

    of solid state properties by incorporating additional components within a single crystal is emerging as a major field of research. 12 These multicomponent solids can be designed as cocrystals or solid solutions (See Figure 3). molecular crystal cocrystal solid solution Figure .

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    cocrystals, solid state forms, solubility, dissolution ...

    Nanostructured Materials in Drug and Gene Delivery: A Review of the State of the Art Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.28, 2011, issue 2 Krutika Sawant, Kailash C. Petkar, Sandip S. Chavhan, Snezana Agatonovik-Kustrin

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    Kinetic Study for Comprehensive Understanding of Solid ...

    Kinetic Study for Comprehensive Understanding of Solid-State Polymorphic Transitions of Nicotinamide/Pimelic Acid Cocrystals Yong Joon Lee,† Olga Pahom,‡ and Brandon L. Weeks*,† †Department of Chemical Engineering and ‡Department of Classical and Modern Languages and Literatures, Texas Tech University, Lubbock, Texas 79409, United States

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    The solid-state continuum: a perspective on the ...

    Rationale solid-state selection (salts, cocrystals) should begin with the assessment of small, compact counterions/coformers to enhance solubility. Although addition of hydrophilic groups to the counterion/coformer can enhance aqueous solubility, the increased H-bonding potential can result in undesirable outcomes, e.g. polymorphism/hydrate ...

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    cocrystals, solid state forms, solubility, dissolution ...

    Nanostructured Materials in Drug and Gene Delivery: A Review of the State of the Art Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.28, 2011, issue 2 Krutika Sawant, Kailash C. Petkar, Sandip S. Chavhan, Snezana Agatonovik-Kustrin

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    solid state chemistry - Cocrystals vs Eutectic mixtures ...

    That explains a eutectic but does not answer the question, which is a good one for solid-state chemists. A cocrystal is a crystalline, multiple component solid with a distinct stoichiometry (molar ratio) between components where a single component is neutral overall(can exist alone without a counter ion, typically non-ionic but a zwitterion counts as a single neutral component) and the ...

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    Solid State R&D - Enantia | Chemistry experts for pharma ...

    Having the optimal solid form of an API is crucial to ensure an optimal bioavailability profile, long-term stability and strong intellectual property strategy. At Enantia, we can help you through the entire process of solid form selection: from initial screening, characterisation, stability and performance tests, to development and scale-up and ...

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    Polymorphism in sulfadimidine/4-aminosalicylic acid ...

    Polymorphism of crystalline drugs is a common phenomenon. However, the number of reported polymorphic cocrystals is very limited. In this work, the synthesis and solid-state characterization of a polymorphic cocrystal composed of sulfadimidine (SD) and .

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